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11 Clinical significance edit Homozygous inheritance of defective PRF1 alleles result in the development of familial hemophagocytic lymphohistiocytosis type 2 (FHL2 a rare and lethal autosomal recessive disorder of infancy.
External links edit Perforin at NLM Genetics Home Reference).A simple gene organization with interesting potential regulatory sequences".Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon casino mauresque arcachon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani.Clementi R, zur Stadt U, Savoldi G,."Regulation of antigen-specific CD8 T cell homeostasis by perforin and interferon-gamma".
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7 Interactions edit Perforin has been shown to interact with calreticulin. The template, infobox gene is being considered for merging. .Doing the right thing is simply the right thing.PRF1 gene and the, prf1 gene in mice."Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin".Offers facts and statistics about more than 8,000,000 locations worldwide, including the population, county, post-code, qiblah, coordinates, local webcams, Wikipedia articles and more.The pore formed allows for the passive diffusion of a family of pro-apoptotic proteases, known as the granzymes, into the target cell.Further reading edit Trapani JA (1996).